| Main Title |
Carcinoma of the Exocrine Pancreas in Medaka. |
| Author |
Fournie, J. W. ;
Hawkins, W. E. ;
Battalora, M. S. J. ;
Walker., W. W. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS. |
| Publisher |
c1991 |
| Year Published |
1991 |
| Report Number |
EPA/600/J-91/341; |
| Stock Number |
PB92-129782 |
| Additional Subjects |
Water pollution effects(Animals) ;
Carcinogens ;
Oryzias ;
Pancreatic neoplasms ;
Benzopyrenes ;
Methylazoxymethanol acetate ;
Carcinogenicity tests ;
Histology ;
Peritoneal neoplasms ;
Reprints ;
Dimethylbenzanthracenes
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-129782 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Eight cases of acinar cell carcinoma of the exocrine pancreas were diagnosed in Japanese medaka (Oryzias latipes) from a pool of approximately 10,000 specimens used in a variety of carcinogenesis bioassays. Three cases occurred in specimens from control groups and one case in a specimen exposed to benzo(e)pyrene (BeP), a noncarcinogenic isomer of benzo(a)pyrene (BaP). Four cases occurred in specimens exposed to known carcinogens including two cases in specimens exposed to 7,12-dimethylbenz(a)anthracene (DMBA), one in a medaka exposed to benzo(a)pyrene, and one in a specimen exposed to methylazoxymethanol acetate (MAM-Ac). Pancreatic carcinoma was probably the cause of death in five cases. The neoplasms appeared to originate in the mesentery near the abdominal surface of the liver. |
| Supplementary Notes |
Pub. in Jnl. of Aquatic Animal Health, v3 p213-220 1991. See also PB88-196266. Prepared in cooperation with Gulf Coast Research Lab., Ocean Springs, MS. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Carcinoma of the Exocrine Pancreas in Medaka. |
| Category Codes |
68D; 57Y; 57E |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
205224023 |
| Origin |
NTIS |
| Type |
CAT |
