| Main Title |
Assessment of Chemically-Induced Alterations in Brain Development Using Assays of Neuron- and Glia-Localized Proteins. |
| Author |
O'Callaghan, J. P. ;
Miller, D. B. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/438; |
| Stock Number |
PB91-109306 |
| Additional Subjects |
Toxicology ;
Brain ;
Nerve cells ;
Reprints ;
Ontogeny ;
Neuroglia ;
Encephalitogenic basic proteins ;
Glial fibrillary acidic protein ;
Organotin compounds
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-109306 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
Chemical intervention during prenatal or postnatal ontogeny can result in complex biochemical, morphological and behavioral alterations in brain development. As has been shown at the conference, the knowledge of specific actions of a given drug/chemical in the adult can serve as a guide for choosing processes affected by the same compound administered during development. Commonly, however, the neuronal or glial substrates for chemical action in the developing brain are not known and cannot be easily predicted on the basis of effects observed in the mature animal. Indeed, there are a multitude of structurally dissimilar compounds that affect diverse and unpredictable targets in the developing brain. The focus of the review is to present an approach for detecting and characterizing chemically-altered brain development that can be used regardless of the information available on the chemical in question. (Copyright (c) 1989 by Intox Press, Inc.) |
| Supplementary Notes |
Pub. in NeuroToxicology (Trade Name), v10 n3 p393-406 Sep 89. Presented at the International Neurotoxicology Conference (6th), Little Rock, AR., October 10-14, 1988. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Assessment of Chemically-Induced Alterations in Brain Development Using Assays of Neuron- and Glia-Localized Proteins. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
034834476 |
| Origin |
NTIS |
| Type |
CAT |
