| Main Title |
Mitochondrial Genetics and Cancer [electronic resource] / |
| Type |
EBOOK |
| Author |
Dakubo, Gabriel D.
|
| Publisher |
Springer Berlin Heidelberg, |
| Year Published |
2010 |
| Call Number |
QH431 |
| ISBN |
9783642114168 |
| Subjects |
Medicine ;
Oncology ;
Human genetics
|
| Internet Access |
|
| Collation |
XV, 356 p. online resource. |
| Notes |
Due to license restrictions, this resource is available to EPA employees and authorized contractors only |
| Contents Notes |
General Overview of Mitochondrial Genetics and Functions -- Basic Mitochondrial Genetics, Bioenergetics, and Biogenesis -- The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells -- Mitochondrial Control of Apoptosis and Cancer -- Mitochondrial-to-Nuclear Communications in Cancer -- Mitochondrial Genetic Alterations in Cancer -- Types of Mitochondrial Genetic Alterations in Cancer -- Mitochondrial Genetic Alterations in Cancer I -- Mitochondrial Genetic Alterations in Cancer II -- Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer -- Functional Importance of Mitochondrial Genetic Alterations in Cancer -- The Role of Mitochondrial Reactive Oxygen Species in Cancer -- Clinical Applications of Mitochondrial Genome Changes in Cancer -- Mitochondrial DNA Measurement in Exfoliated Cells for Cancer Detection and Monitoring: The Copy Number Advantage -- Early Cancer Detection and Monitoring Using Changes in the Mitochondrial Genome as Biosensors -- Analysis of Mitochondrial Genome Alterations in Cancer -- "Mitocans": Agents Targeting Mitochondria to Kill Cancer Cells. The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance. |
| Place Published |
Berlin, Heidelberg |
| Corporate Au Added Ent |
SpringerLink (Online service) |
| Host Item Entry |
Springer eBooks |
| PUB Date Free Form |
2010 |
| BIB Level |
m |
| Medium |
computer |
| Content |
text |
| Carrier |
online resource |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20141129031440 |
| Language |
eng |
| Origin |
SPRINGER |
| Type |
EBOOK |
| OCLC Rec Leader |
03280nam a22004575i 45 |
