||Metabolism of Octamethylcyclotetrasiloxane in the Monkey with Attachments and Cover Letter Dated 05/21/1988.
||Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Octamethylcyclotetrasiloxane (556-67-2) ;
Pharmaco Kinetics ;
Toxic substances ;
Laboratory animals ;
CAS No 556-67-2
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||The absorption, distribution, metabolism and elimination of octamethylcyclotetrasiloxane were investigated in 2 monkeys administeredsingle oral doses at a level of 50 mg/kg. The C14-labeled test article was distributed throughout the body and it was absorbed mainly from the gastrointestinal tract. Residual 14C tissue levels 240 hours after oral dosing in microgram/gm equiv. were the following; 3.6 in lymph node, 8.4in mesentery, 13.1 in fat and 5.3 in liver. The major portion of radioactivity excreted was found in the urine with total recoveries of C14 at 63% and 52% while fecal recoveries were 11% and 16% of C14. Threemetabolites were observed; dimethylsilanediol, tetramethyl-1,3-disiloxane diol and hexamethyl-1,5-trisiloxane diol. Themetabolism closely paralled that of 2,6-cis and 2,6-trans-diphenylhexame thylcyclotetrasiloxane.
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