||Effects of Repeated Whole Body Inhalation Exposure to Octamethylcyclotetasiloxane (D4) Vapors on Hepatic Microsomal CYP2B1/2 Induction in Rats, with Cover Letter dated 02/25/1999.
||Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Chronic toxicity ;
Cell transportation ;
CAS No 556-67-2
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Previous studies within Dow Corning have shown that repeated inhalation exposure to OctamethyIcyclotetrasiloxane (D4) produces reversible hepatomegaly and dose-dependent induction of hepatic microsomal CYP2B1/2 enzymes. Maximum induction of CYP2B1/2 was achieved between 5 and 7 days of exposure. However, a detailed dose-response curve for the induction of CYP2B1/2 has not been determined. Moreover, the amount of D4 in the liver, blood, and fat over a wide exposure range has not been shown. Therefore, the objective of this study was to provide a complete dose-response profile for the induction of CYP2B1/2 activity in rat hepatic microsomes that can be related to exposure concentration and tissue dose.
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|PUB Date Free Form
||2 Mar 1999
||57Y; 57U; 68G; 99; 44G
||PC A20/MF A20