| Main Title |
Effects of Repeated Whole Body Inhalation Exposure to Octamethylcyclotetasiloxane (D4) Vapors on Hepatic Microsomal CYP2B1/2 Induction in Rats, with Cover Letter dated 02/25/1999. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1999 |
| Stock Number |
OTS0573879 |
| Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane ;
Chronic toxicity ;
Cell transportation ;
Mammals ;
Rats ;
Inhalation ;
CAS No 556-67-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573879 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
431p |
| Abstract |
Previous studies within Dow Corning have shown that repeated inhalation exposure to OctamethyIcyclotetrasiloxane (D4) produces reversible hepatomegaly and dose-dependent induction of hepatic microsomal CYP2B1/2 enzymes. Maximum induction of CYP2B1/2 was achieved between 5 and 7 days of exposure. However, a detailed dose-response curve for the induction of CYP2B1/2 has not been determined. Moreover, the amount of D4 in the liver, blood, and fat over a wide exposure range has not been shown. Therefore, the objective of this study was to provide a complete dose-response profile for the induction of CYP2B1/2 activity in rat hepatic microsomes that can be related to exposure concentration and tissue dose. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2 Mar 1999 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A20/MF A20 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028701390 |
| Origin |
NTIS |
| Type |
CAT |
