| Main Title |
Bacterial Mutation Assay of Dow Corning 344 Fluid, with Cover Letter dated 10/16/1998. |
| CORP Author |
Huntingdon Life Sciences, Ltd.; Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1998 |
| Stock Number |
OTS0573854 |
| Additional Subjects |
Toxicology ;
Health effects ;
Octamethylcyclotetrasiloxane ;
Genotoxicity ;
Gene mutations ;
Bacteria ;
In vitro ;
CAS No 541-02-6 ;
CAS No 541-05-9 ;
CAS No 556-67-2 ;
CAS No 69430-24-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0573854 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
31p |
| Abstract |
In this in vitro assessment of the mutagenic potential of Dow Corning 344 Fluid, histidine dependent auxotrophic mutants of Salmonella typhimurium (strains TAl535, TAl537, TA98 and TA100) and tryptophan dependent mutants of Escherichia coli (strains WP2 and WP2 uvrA) were exposed to the test substance diluted in ethanol, which was also used as a negative control. A preliminary toxicity test and two independent mutation tests were performed in the presence and absence of liver preparations from Aroclor 1254-induced rats (S9 mix). All the tests included a pre-incubation stage. Dose levels of up to 5000 ug/plate were tested in the preliminary toxicity test. This is the standard limit dose recommended in the regulatory guidelines this assay follows. No signs of toxicity were observed towards the tester strains so 5000 ug/plate was again chosen as the highest concentration in the main mutation test. Other dose levels used were a series of ca half-loglo dilutions of the highest concentration (1500, 500, 150 and 50 ug/plate). No evidence of mutagenic activity was seen at any dose level of Dow Corning 344 Fluid in either mutation test. The concurrent positive controls demonstrated the sensitivity of the assay and the metabolising activity of the liver preparations. It is concluded that, when tested in ethanol, Dow Corning 344 Fluid shows no evidence of mutagenic activity in this Bacterial Reverse Mutation Assay. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
23 Oct 1998 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028701150 |
| Origin |
NTIS |
| Type |
CAT |
