| Main Title |
Letter from Rhom and Haas Company to US EPA regarding Submission of Abstract and Summary Pages from Draft Epidemiology Study using Chloromethyl Ethers with Attachments. |
| CORP Author |
Rohm and Haas Co., Bristol, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
26 Jul 1990 |
| Year Published |
1990 |
| Report Number |
FYI-OTS-0790-0776; |
| Stock Number |
OTS-0000776 |
| Additional Subjects |
Respiratory system diseases ;
Epidemiology ;
Chloromethyl ethers ;
Toxic substances ;
Neoplasms ;
Occupational exposure ;
Lung cancer ;
Diagnosis(Medicine) ;
Carcinogens ;
Induction ;
Dose-response relationships ;
Humans ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0000776 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
53p |
| Abstract |
Lung cancers occurred at a higher rate among workers who had been potentially exposed in the past to chloromethyl-methyl- ether/bis-chloromethyl-ether than among unexposed workers at the same plant (RR 4.4, 95%Cl 1.8-10.9), or among an externalreference population (RR 4.4, 95%CI 5.5-10). The average age at diagnosis among the exposed was at least 10.5 years lower than among theunexposed. The predominantly small-cell cancers of the exposed were mostly oat-cell, a characteristic of lung cancers in groups exposed to CMME/BCME. There was a positive dose response. The mean time from first exposure to diagnosis was 13 years (95%CI 8-18 years). Dose and induction time were not associated. The rate for the exposed workers peaked somewhere between 7 and 13 years after the start-up of the process, and has declined since. It is impossible to say if the period of excess rate has passed completely, but there are indications that it is essentially over. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC. |
| Availability Notes |
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| Category Codes |
57E; 57Y; 57U; 68G |
| NTIS Prices |
PC A05/MF A01 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
035500220 |
| Origin |
NTIS |
| Type |
CAT |
