| Main Title |
Short-Term Clinical and Neuropathologic Effects of Cholinesterase Inhibitors in Rats. |
| Author |
Ehrich, M. ;
Shell, L. ;
Rozum, M. ;
Jortner, B. S. ;
|
| CORP Author |
Virginia-Maryland Regional Coll. of Veterinary Medicine, Blacksburg, VA. ;Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Statistics.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1993 |
| Year Published |
1993 |
| Report Number |
EPA-68D80098; EPA/600/J-94/397; |
| Stock Number |
PB95-126462 |
| Additional Subjects |
Cholinesterase inhibitors ;
Nervous system ;
Pathology ;
Organophosphate insecticides ;
Reprints ;
Rats ;
Dose-response relationships ;
Tables(Data) ;
Myelin sheath ;
Functional observation battery
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-126462 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
Adult male Long Evans rats were given a single administration of 3 dosage levels of the organophosphorus compounds tri-ortho-tolyl phosphate (TOTP), diisopropyl fluorophosphate (DFP), phenyl saligenin phosphate (PSP), mipafox, malathion, and dichlorvos or the carbamate carbaryl. Acetylcholinesterase and neurotoxic esterase activities were inhibited in a dose-dependent manner, with the highest dosages of all these compounds inhibiting activities of these enzymes in brain by at least 37% and 64%, respectively, at 4 and 48 hours after administration. Rats given the high doses of TOTP (1000 mg/kg), DFP (3 mg/kg), malathion (2000 mg/kg), and carbaryl (160 mg/kg) weighed significantly less than control rats 14 days after administration. A functional observational battery (FOB) was used to screen for neurotoxic effects 1, 2, and 3 weeks after exposure. All 7 test compounds were capable of causing changes in parameters indicative of behavioral and central nervous system excitability. In addition, dose-related alterations in response to approach were seen in rats given DFP, malathion, dichlorvos, and carbaryl. |
| Supplementary Notes |
Pub. in Jnl. of the American College of Toxicology, v12 n1 p55-68 Feb 93. Prepared in cooperation with Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Statistics. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Short-Term Clinical and Neuropathologic Effects of Cholinesterase Inhibitors in Rats. |
| Category Codes |
57Y; 57O; 68E |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
435318862 |
| Origin |
NTIS |
| Type |
CAT |
