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OLS Field Name OLS Field Data
Main Title Effect of Phenobarbitol on the Gamma-Glutamyltranspeptidase Activity and the Remodeling of Nodules Induced by the Initiation-Selection Model.
Author Herren-Freund, S. L. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1985
Report Number EPA/600/J-85/162;
Stock Number PB86-107216
Additional Subjects Environmental surveys ; Phenobarbital ; Enzymes ; Toxicology ; Laboratory animals ; Dosage ; Exposure ; Rats ; Mathematical models ; Liver diseases ; Reprints ; Nitrosamine/diethyl ; Transpeptidase/glutamyl ; Cancer
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NTIS  PB86-107216 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 11p
Abstract Enzyme-altered foci and nodules have been observed in the liver of rats treated with diethylnitrosamine(DENA) followed by selection with 0.02% 2-acetylaminofluorene (2-AAF) and a partial hepatectomy (PH) (DENA-2AAF-PH treatment). The authors determined the effect of subsequent administration of phenobarbital or of a second dose of DENA on the progression or reversion of these lesions. After the removal of 2-AAF from the diet, one group of rats received no further treatment, another group received subsequent exposure to phenobarbital, a third group received a second dose of DENA, and a fourth group received a second dose of DENA without the partial hepatectomy during the 2-AAF exposure. The rats were sacrificed at various times up to 58 weeks following the 2-AAF exposure. Subsequent exposure to phenobarbital did not alter the tumor incidence in the DENA-2AAF-PH treated rats while the second dose of DENA resulted in an increased incidence of hyperplastic nodules and hepatocellular carcinomas as well as an increase in renal tubular adenomas and carcinomas.
Availability Notes Pub. in Cancer Letters 27, p153-161 Jun 85.
NTIS Title Notes Journal article.
Title Annotations Reprint: Effect of Phenobarbitol on the Gamma-Glutamyltranspeptidase Activity and the Remodeling of Nodules Induced by the Initiation-Selection Model.
PUB Date Free Form c1985
Category Codes 6T; 6A; 7D; 57Y; 68G; 57B; 99A
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 535326985
Origin NTIS
Type CAT