| Main Title |
Chronic Inhalation Exposure to Rats and Rabbits with Nitromethane and 2-nitropropane (Final Report) with Attachments and Cover Letter Dated 08/10/1989. |
| CORP Author |
Huntingdon Research Center, Inc., Baltimore, MD.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1989 |
| Report Number |
86-890001529 |
| Stock Number |
OTS0520658 |
| Additional Subjects |
Toxicology ;
Health effects ;
Nitromethane (75-52-5) ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Chronic Toxicity ;
Rabbits ;
Toxic substances ;
Laboratory animals ;
CAS No 75-52-5 ;
CAS No 79-46-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0520658 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
239p |
| Abstract |
Groups of 50 male Sprague-Dawley rats and 15 male New Zealand white rabbits were exposed by inhalation for 7 hours/day, 5 days/week for 6 months to nitromethane (exposure concentrations of 100 and 750 ppm) or 2-nitropropane (25 and 200 ppm). Exposure to nitromethane caused reduced body weight gain and slightly depressed hematocrit and hemoglobin levels in high-dose rats, and in rabbits it induced elevated ornithine carbamyl transferase and possibly depressed hemoglobin levels. Some evidence of pulmonary edema and other pulmonary abnormalities were seen at 1 month post-treatment in rabbits of both dose groups. Exposure to 2-nitropropane induced elevated ornithine carbamyl transferase in high-dose rabbits but not rats. Liver weights were elevated in high-dose animals of both species, accompanied by severe neoplastic changes in livers of rats. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Rohm and Haas Co., Philadelphia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1989 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A12/MF A12 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802090 |
| Origin |
NTIS |
| Type |
CAT |
