Main Title |
Pulmonary Function in Juvenile and Young Adult Rats Exposed to Low-Level NO2 with Diurnal Spikes. |
Author |
Stevens, M. A. ;
Menache, M. G. ;
Crapo, J. D. ;
Miller, F. J. ;
Graham, J. A. ;
|
CORP Author |
Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1988 |
Report Number |
EPA-68-02-4032; EPA/600/J-88/020; |
Stock Number |
PB88-219720 |
Additional Subjects |
Respiratory system ;
Exposure ;
Rats ;
Nitrogen dioxide ;
Lung ;
Concentration(Composition) ;
Ventilation ;
Reprints ;
Pulmonary function ;
Lung compliance ;
Health effects
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB88-219720 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Pulmonary function was examined in juvenile and young adult Fischer-344 rats continuously exposed to NO2 (0.5, 1.0 or 2.0 ppm) for up to 6 weeks with twice daily 1 hr spikes equal to 3X the baseline concentration. The spike to baseline ratio was chosen to simulate morning and evening urban rush hour conditions. Juvenile rats were examined after 3 and 6 weeks of NO2 exposures, while young adult rats were examined after 1, 3, and 6 week intervals. Lung volumes, compliance, and efficiency of ventilation were evaluated. Lung volumes increased in the juvenile rats after 3 and 6 week exposures to 1.0 and 2.0 ppm, but were unchanged in young adult rats. Lung compliance increased in juvenile rats exposed to 1.0 or 2.0 ppm for 3 weeks, however, was unchanged in juvenile rats exposed for 6 weeks, as well as in the young adult rats exposed for 1 and 3 weeks. Compliance decreased in young adult rats exposed to 2.0 ppm for 6 weeks, and was correlated to an overall thickening of alveolar interstitium and spetal tissues. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v23 p229-240 1988. Prepared in cooperation with Duke Univ. Medical Center, Durham, NC. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Pulmonary Function in Juvenile and Young Adult Rats Exposed to Low-Level NO2 with Diurnal Spikes. |
PUB Date Free Form |
c1988 |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
826014789 |
Origin |
NTIS |
Type |
CAT |