| Main Title |
Biosynthesis of Dimethylnitrosamine in Dimethylamine-Treated Mice After Exposure to Nitrogen Dioxide. |
| Author |
Iqbal, Zafar M. ;
Dahl, Kristine ;
Epstein, Samuel S. ;
|
| CORP Author |
Illinois Univ. at the Medical Center, Chicago.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-R-807293; EPA-600/J-81-609; |
| Stock Number |
PB83-169706 |
| Additional Subjects |
Nitrogen dioxide ;
Biosynthesis ;
Ingestion(Biology) ;
Mice ;
Exposure ;
Laboratory animals ;
Dimethylamine ;
Nitrogen organic compounds ;
Reprints ;
Dimethylamine/N-nitroso
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-169706 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
These studies demonstrate the nitrosating potential of NO2 in vivo in 1CR mice. Groups of mice were gavaged with 2 mg dimethylamine (DMA) and exposed to NO2 at levels from 0.04 to 44.5 ppm for periods up to 4 hours. Mice were individually frozen and blended to a powder, aliquots of which were homogenized in ice-cold dichloromethane and 35% aqueous methanol. Concentrates of organic extracts were analyzed for dimethylnitrosamine (DMN) by a Thermal Energy Analyzer with a gas chromatograph interface. Biosynthesis of DMN was dose- and time-dependent with relation to NO2 exposure, reaching a maximum yield of 60-70 ng/mouse (0.0034% DMA conversion) at 2 hours. DMN biosynthesis was inhibited by sodium ascorbate and, more effectively, by ammonium sulfamate. |
| Supplementary Notes |
Pub. in Jnl. of the National Cancer Institute, v67 n1 p137-141 Jul 81. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Biosynthesis of Dimethylnitrosamine in Dimethylamine-Treated Mice After Exposure to Nitrogen Dioxide. |
| PUB Date Free Form |
1981 |
| Category Codes |
6T; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
315023484 |
| Origin |
NTIS |
| Type |
CAT |
