| Main Title |
Examination of the Anticonvulsant Properties of Voltage-Sensitive Calcium Channel Inhibitors in Amygdala Kindled Seizures. |
| Author |
Mack, C. M. ;
Bilbert., M. E. ;
|
| CORP Author |
ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/143; |
| Stock Number |
PB92-166776 |
| Additional Subjects |
Anticonvulsants ;
Calcium channel blockers ;
Amygdala ;
Kindling(Neurology) ;
Nitrendipine ;
Verapamil ;
Nimodipine ;
Flunarizine ;
Dose-response relationships ;
Pharmacology ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-166776 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Representatives from three different classes of voltage-sensitive calcium (VSC) channel inhibitors were assessed for their protection against amygdala kindled seizures. Adult male Long Evans rats (n=12) were implanted with electrodes in the amygdala and were stimulated once daily until generalized stage 5 seizures (GS) were observed. Subsequently a minimum stimulus intensity required to evoke a GS was determined. The Ca(sup 2+)-channel antagonists (nimodipine 0,5,25,50 mg/kg; nitrendipine 0,25,50,100 mg/kg; verapamil 0,10,20,40 mg/kg and flunarizine 0,20,40,80 mg/kg) were administered po 60-90 mins prior to amygdala stimulation at the established threshold. None of the drugs altered threshold for inducing a seizure. The phenylalkylamine, verapamil, and the dihydropyridines nimodipine and nitrendipine, were without effect on amygdala kindled seizures. The diphenylalkylamine flunarizine (80 mg/kg) produced a significant reduction in seizure severity (25%), AD duration (63%), and duration of clonic seizure activity (69%). It was concluded that non-NMDA Ca(sup 2+)-channel antagonists do possess anticonvulsant properties and do so in the absence of any overt signs of toxicity. The diphenylalkylamine flunarizine is the most efficacious. Thus voltage sensitive Ca(sup 2+)-channels, distinct from the NMDA mediated channel, may contribute to epileptiform activity induced by kindling. (Copyright (c) Springer-Verlag 1992.) |
| Supplementary Notes |
Pub. in Psychopharmacology, v106 n3 p365-369 Mar 92. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Examination of the Anticonvulsant Properties of Voltage-Sensitive Calcium Channel Inhibitors in Amygdala Kindled Seizures. |
| Category Codes |
57Q; 57I |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
216423485 |
| Origin |
NTIS |
| Type |
CAT |
