| Main Title |
Effects of Nickel on Immune Function in the Rat. |
| Author |
Smialowicz, R. J. ;
Rogers, R. R. ;
Rowe, D. G. ;
Riddle, M. M. ;
Luebke, R. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/110; |
| Stock Number |
PB88-140488 |
| Additional Subjects |
Nickel ;
Toxicology ;
Rats ;
Cytology ;
Inhibition ;
Antibodies ;
Laboratory animals ;
Reprints ;
Immune systems ;
Natural killer cells ;
Tumor initiators ;
Immune response antigens ;
Carcinogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-140488 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The immunotoxic potential of NiCl2 was evaluated in Fischer 344 rats following a single intramuscular injection at doses ranging from 10 to 20 mg/kg. Twenty-four hours following treatment, selected cellular and humoral immune function parameters were examined. Significant (P>0.05) decreases in body weights were observed in rats injected with 15 and 20 mg/kg NiCl2 as were decreased in spleen weights of rats receiving 20 mg/kg. The lymphoproliferative responses of splenocytes to the T cell mitogens concanavalin A (ConA), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) and the B cell mitogen Salmonella typhimurium mitogen (STM) were not significantly different from controls. No significant differences were observed between control and Ni-treated rats in the primary antibody response to sheep red blood cells (SRBC). On the other hand, natural killer (NK) cell activity was significant (P<0.05) suppressed in rats injected with 10, 15, or 20 mg/kg NiCl2. NK cell suppression was observed in both male and female rats and for both allogeneic W/Fu-G1 target cells as well as xenogeneic YAC-1 target cells. Ni-induced suppression of NK activity was transient, with levels returning to control values within three days following treatment. Ni-induced suppression of NK activity was also manifested by an increase in mortality of rats injected with MADB106 tumor cells. |
| Supplementary Notes |
Pub. in Toxicology, v44 p271-281 1987. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effects of Nickel on Immune Function in the Rat. |
| PUB Date Free Form |
1987 |
| Category Codes |
57J; 57Y; 57O; 68G |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
807117687 |
| Origin |
NTIS |
| Type |
CAT |
