Main Title |
Glutamate Neurotoxicity in the Developing Rat Cochlea is Antagonized by Kynurenic Acid and MK-801. |
Author |
Janssen, R. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
c1992 |
Year Published |
1992 |
Report Number |
EPA/600/J-92/024; |
Stock Number |
PB93-141349 |
Additional Subjects |
Toxicity ;
Cochlea ;
Nervous system ;
Glutamates ;
Kynurenic acid ;
Dizocilpine maleate ;
Ganglia ;
Hair cells ;
Afferent neurons ;
Rats ;
Newborn animals ;
Neurotoxins ;
Reprints ;
Glutamate antagonists ;
Ototoxicity
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-141349 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
Glutamate (Glu) is neurotoxic in the neonatal rat cochlea, producing hearing impairment which is largely due to the death of spiral ganglion cells, whereas the receptor hair cells are spared. Dendritic processes of the spiral ganglion are postsynaptic to the primary afferent synapse of the auditory system. The experiments reported here were designed to test whether this apparent excitotoxicity can be blocked by Glu antagonists. (Copyright (c) 1992 Elsevier Science Publishers B.V.) |
Supplementary Notes |
Pub. in Brain Research, v590 n1-2 p201-206, 11 Sep 92. See also PB92-113240 and PB91-233403. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Glutamate Neurotoxicity in the Developing Rat Cochlea is Antagonized by Kynurenic Acid and MK-801. |
Category Codes |
57Y; 57F; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
307031413 |
Origin |
NTIS |
Type |
CAT |