Main Title |
Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex. |
Author |
Crofton, K. M. ;
Reiter, L. W. ;
Mailman, R. B. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. |
Year Published |
1987 |
Report Number |
EPA/600/J-87/050; |
Stock Number |
PB87-212445 |
Additional Subjects |
Insecticides ;
Toxicology ;
Rats ;
Ligands ;
Synapses ;
Hazardous materials ;
Reprints ;
Pyrethrins ;
Neurotoxins ;
Receptors(Gaba-benzodiazepine) ;
FLU(Flunitrazepam) ;
TBPS(t-butylbicyclophosphorothionate) ;
MUS(Muscimol)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB87-212445 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Radioligand binding displacement studies were conducted to determine the effects of Type I and II pyrethroids on (3H)-flunitrazepam (FLU), (3H)-muscimol (MUS), and (35S)t-butylbicyclophosphorothionate (TBPS) binding. Competition experiments with (3H)-FLU and (3H)-MUS indicate a lack of competition for binding by the pyrethroids. Type I pyrethroids failed to compete for the binding of (35S)-TBPS at concentrations as high as 50 pM. Type II pyrethroids inhibited (35S)-TBPS binding to rat brain synaptosomes with Ki values ranging from 5-10 pM. The data presented here suggest that the interaction of Type II pyrethroids with the GABA receptor-ionophore complex is restricted to a site near the TBPS/picrotoxinin binding site. |
Supplementary Notes |
Pub. in Toxicology Letters, v35 p183-190 1987. Prepared in cooperation with North Carolina Univ. at Chapel Hill. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Pyrethroid Insecticides and Radioligand Displacement from the GABA Receptor Chloride Ionophore Complex. |
PUB Date Free Form |
c1987 |
Category Codes |
57Y; 68E; 68G |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
728119497 |
Origin |
NTIS |
Type |
CAT |