| Main Title |
Mechanisms Underlying Somatosensory Cortical Dynamics: 2. In vitro Studies. |
| Author |
Lee, C. J. ;
Whitsel, B. L. ;
Tommerdahl, M. ;
|
| CORP Author |
North Carolina Univ. at Chapel Hill. Dept. of Psychology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA-R-818321010; EPA/600/J-92/376; |
| Stock Number |
PB93-107225 |
| Additional Subjects |
Somatosensory cortex ;
Neurons ;
Neurophysiology ;
In vitro analysis ;
Evoked potentials ;
Electric stimulation ;
Rats ;
Deoxyglucose ;
Metabolism ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-107225 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
The response of the sensorimotor cortical slice to repetitive, single site afferent drive is mapped using both evoked potential and metabolic mapping (2DG) methods. Systematic changes (increases or decreases) in the evoked potential occur during repetitive 3-5 Hz stimulation. Place, timing, and intensity of repetitive stimulation influence the amplitude and form of the response alterations observed at a given cortical locus. The neuron populations which exhibit different response modifications to the same repetitive stimulus are distributed non-randomly in the slice: neurons occupying column-shaped aggregates undergo a common response alteration (either an increase or decrease) during repetitive stimulation, with sharp boundaries separating neighboring aggregates distinguishable on the basis of their dynamic behaviors. The distribution of stimulus-evoked 2DG uptake in the slice is columnar, the dimensions of the 2DG columns corresponding to those mapped with neurophysiological methods. Taken together, the findings support the concept (Whitsel et al., 1991) that repetitive stimulation causes the intrinsic network of somatosensory cortex to dynamically modify the network's response to extrinsic excitatory drive so that the local differences in the pattern of extrinsic excitatory drive to neighboring cortical columns are enhanced. |
| Supplementary Notes |
Pub. in Cerebral Cortex Jnl. v2 n2 p107-133 Mar/Apr 92. See also PB93-107217. Color illustrations reproduced in black and white. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Mechanisms Underlying Somatosensory Cortical Dynamics: 2. In vitro Studies. |
| Category Codes |
57I; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
234225656 |
| Origin |
NTIS |
| Type |
CAT |
