| Main Title |
Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'. |
| Author |
Fournie, J. W. ;
Hawkins, W. E. ;
Overstreet, R. M. ;
Walker, W. W. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.;National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology.;Army Medical Research and Development Command, Washington, DC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/309; N01-CP-2-6008; |
| Stock Number |
PB88-196266 |
| Additional Subjects |
Organic compounds ;
Pancreatic neoplasms ;
Fresh water fishes ;
Water pollution ;
Carcinogens ;
Exposure ;
Histology ;
Sampling ;
Malignant neoplasms ;
Humans ;
Laboratory animals ;
Adenoma ;
Adenocarcinomas ;
Cells(Biology) ;
Tests ;
Cytoplasm ;
Photomicrographs ;
Reprints ;
Methylazoxymethanol acetate ;
MAM-Ac ;
Poecilla reticulata ;
Guppy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-196266 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
Exocrine pancreatic neoplasms developed in the guppy Poecillia reticulata following a single brief exposure to methylazoxymethanol acetate. Fish 6-10 days old were exposed to concentrations of MAM-Ac up to 100 mg/liter for 2 hours. Exposed specimens were transferred to carcinogen-free water and sampled periodically for tumor development. Pancreatic neoplasms occurred in approximately 9% of histologically examined individuals exposed to 10 mg MAM-Ac/liter or less. Neoplastic lesions were not found in 122 control specimens. The neoplasms included 6 cases diagnosed as adenoma, 7 cases diagnosed as acinar cell carcinoma, and 2 cases diagnosed as adenocarcinoma. The findings of carcinogen-induced pancreatic neoplasms in guppies further strengthen the usefulness of small fish species in carcinogen testing. |
| Supplementary Notes |
Pub. in Jnl. of the National Cancer Institute, v78 n4 p715-725 Apr 87. Prepared in cooperation with Gulf Coast Research Lab., Ocean Springs, MS. Sponsored by National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology, and Army Medical Research and Development Command, Washington, DC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'. |
| PUB Date Free Form |
c1987 |
| Category Codes |
68D; 57; 57Z |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
817624619 |
| Origin |
NTIS |
| Type |
CAT |
