| Main Title |
Evaluation of the potential carcinogenicity of dinitrotoluene (mixture) (25321-14-6) / |
| CORP Author |
Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; |
| Year Published |
1988 |
| Report Number |
EPA/600/8-91/122; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-097 |
| Stock Number |
PB93-185395 |
| Subjects |
Dinotrotoluene--Carcinogenicity
|
| Additional Subjects |
Toxicity ;
Risk assessment ;
Exposure ;
Public health ;
Hazardous materials ;
Neoplasms ;
Tolerances(Physiology) ;
DNT(Dinitrotoluenes) ;
Carcinogenicity ;
Dose-response relationships ;
CAS Registry No: 25321-14-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-185395 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19 pages ; 28 cm |
| Abstract |
Carcinogenicity data for mixed dinitrotoluenes are inadequate. Since the technical grade mixture consists of approximately 75 percent 2,4-dinitrotoluene and 19.5 percent 2,6-dinitrotoluene, hazard assessment for the mixture can be based on experimentation with the 2,4-isomer. Dinitrotoluene (mixture) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is No Data. The potency factor (F) for dinitrotoluene (mixed) is the same as the factor for 2,4-dinitrotoluene, which is 3,82 (mg/kg/day)(-1). Therefore, dinitrotoluene (mixture) can be placed in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, dinitrotoluene (mixture) is assigned a MEDIUM hazard ranking. |
| Notes |
Cover title. "June 1988." Includes bibliographical references. Microfiche. |
| Place Published |
Washington, D.C. : |
| Supplementary Notes |
See also PB93-185411 and PB88-218961. Prepared in cooperation with Environmental Monitoring and Services, Inc., Washington, DC. Sponsored by Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Corporate Au Added Ent |
United States. Environmental Protection Agency. Office of Health and Environmental Assessment. Carcinogen Assessment Group. |
| PUB Date Free Form |
{1988} |
| NTIS Prices |
PC A03/MF A01 |
| BIB Level |
m |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20010404172144 |
| Language |
eng |
| Origin |
NTIS |
| Type |
MERGE |
| OCLC Rec Leader |
01146nam 2200253Ka 45020 |
