Main Title |
Comparison of Rat Liver Foci Assay and Strain a Mouse Lung Tumor Assay to Detect Carcinogens: A Review. |
Author |
Pereira, M. A. ;
Stoner, G. D. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Medical Coll. of Ohio at Toledo. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/222; |
Stock Number |
PB86-118650 |
Additional Subjects |
Toxicology ;
Malignant neoplasms ;
Bioassays ;
Rats ;
Liver ;
Mice ;
Comparison ;
Reprints ;
Carcinogenesis ;
Cancer
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-118650 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
A comparison was performed of the results reported in the literature of chemicals tested in the rat liver foci assay and/or in the strain A lung tumor assay to the results of the chemicals in long-term carcinogenicity bioassays. The rat liver foci assay was sensitive to 69% of 54 compounds found to be carcinogenic in long-term bioassays and the strain A lung tumor assay to 54% of 93 carcinogens. None of the ten compounds found to be noncarcinogenic in long-term bioassays were active in the rat liver foci assay, while seven of 23 non-carcinogens (30%) were active in the lung tumor assay. Ten of the 16 carcinogens negative in the rat liver foci assay are believed to be tumor promoters; 3 are direct-acting alkylating agents (dimethylsulfate, epichlorohydrin, and beta-propiolactone); and the remaining 4 are azobenzene, 1,2-dibromoethane, oxazepam and thioacetamide. |
Supplementary Notes |
Prepared in cooperation with Medical Coll. of Ohio at Toledo. |
Availability Notes |
Pub. in Fundamental and Applied Toxicology 5, p688-699 1985. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Comparison of Rat Liver Foci Assay and Strain a Mouse Lung Tumor Assay to Detect Carcinogens: A Review. |
PUB Date Free Form |
c1985 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
603115780 |
Origin |
NTIS |
Type |
CAT |