Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 2 OF 3

OLS Field Name OLS Field Data
Main Title Lack of Myoglobin Function in the Isolated Perfused Buffalo Sculpin('Enophrys bison') Heart.
Author Nichols, J. W. ; Weber, L. J. ;
CORP Author Environmental Research Lab.-Narragansett, Newport, OR. Mark O. Hatfield Marine Science Center.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-90/248;
Stock Number PB91-144964
Additional Subjects Myoglobin ; Heart ; Buffaloes ; Oxygen consumption ; Heart function tests ; In vitro analysis ; Dose-response relationships ; Heart rate ; Reprints ; Enophrys bison ; Phenylhydroxylamine
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-144964 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/13/1991
Collation 7p
Abstract The contribution of myoglobin to cardiac performance and O2 consumption was investigated using an isolated perfused buffalo sculpin (Enophrys bison) heart preparation. Dose-response studies at ambient (150 Torr)(1 Torr=133.322 Pa) O2 tensions were conducted as a means of selecting an oxidizing agent with high activity toward myoglobin, while minimizing the possibility of toxic side effects. Treatment with 10.0 microM phenylhydroxylamine oxidized greater than 95% of intracellular myoglobin but did not affect pulse pressure, peak dP/dt, or heart rate. The functional importance of myoglobin was investigated by perfusing electrically paced hearts with 10.0 microM phenylhydroxylamine at physiological (32 Torr) O2 tensions. Inactivation of myoglobin by oxidation with phenylhydroxylamine had no effect on cardiac performance or O2 consumption.
Supplementary Notes Pub. in Canadian Jnl. of Zoology, v68 p825-829 May 90. Sponsored by National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Lack of Myoglobin Function in the Isolated Perfused Buffalo Sculpin('Enophrys bison') Heart.
Category Codes 57F; 57S
NTIS Prices PC A02/MF A01
Primary Description 600/05
Document Type NT
Cataloging Source NTIS/MT
Control Number 109129951
Origin NTIS
Type CAT