| Main Title |
Genetic Evaluation of Silastic Q7-2867 (Polydimethylsiloxane) in Bacterial Reverse Mutation Assays with Cover Letter dated 04/20/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001412 |
| Stock Number |
OTS0590116 |
| Additional Subjects |
Toxicology ;
Health effects ;
Siloxanes/Silicones ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 63148-62-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0590116 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
22p |
| Abstract |
Polydimethylsiloxane (PDMS) fluid was evaluated for mutagenic potential in the Salmonella typhimurium and Escherichia coli Reverse Mutation assays as described in EEC Directive No.L251. Mutagenicity was evaluated by measuring the ability of PDMS fluid to produce reverse mutations in several strains of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and Escherichia coli (WP2) in the presence and absence of Aroclor-induced rat liver microsomal enzymes. Concentrations of 0 (solvent control), 312.5, 625, 1250, 2500, and 5000 ug/plate, along with positive controls, were plated with each tester strain in the presence or absence of microsomal enzymes. Sodium azide, 9-amino acridine, 2- nitrofluorene, n-methyl-n-nitrosoguanidine, and 2-anthramine served as positive controls. Initially, contamination was observed in the TA98 and WP2 plates, and these tests were rerun. No mutagenic responses were observed in any strain tested in the absence or presence of microsomal enzymes. Under the conditions of this study, PDMS fluid was not mutagenic. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804390 |
| Origin |
NTIS |
| Type |
CAT |
