| Main Title |
Genetic Evaluation of Recovered Hexamethyldisiloxane in the Ames Bacterial Assay, with Cover Letter dated 4/20/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001361 |
| Stock Number |
OTS0558142 |
| Additional Subjects |
Toxicology ;
Health effects ;
Hexamethyldisiloxane (107-46-0) ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 107-46-0
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558142 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
This study evaluated the mutagenic potential of methyl disiloxane in the Ames assay using Salmonella typhimurium. Mutagenicity was evaluated by measuring the ability of methyl disiloxane to produce reverse mutations in several strains of Salmonella typhimurium (TA1535, TA1537, TA 1538, TA98, TA100) in the presence and absence of Aroclor-induced rat liver microsomal enzymes. The study consisted of two phases. The first phase was the spot plate test in which methyl disiloxane diluted in ethanol was spotted on individual plates of each strain, in the absence or presence of microsomal enzymes. In the second phase, concentrations of 0 (solvent control), 312.5, 625, 1250, 2500, or 5000 ug/plate, along with positive controls, were plated with each tester strain in the presence or absence of microsomal enzymes. Sodium azide, 9-amino acridine, 2-nitrofluorene, and 2-anthramine served as positive controls. No mutagenic responses were produced by the methyl disiloxane in either phase in any strain tested in the absence or presence of microsomal enzymes. Under the conditions of this study, methyl disiloxane was not mutagenic. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803870 |
| Origin |
NTIS |
| Type |
CAT |
