| Main Title |
Genetic Evaluation of dow Corning Q4-2797 in Bacterial Reverse Mutation Assays, with Cover Letter dated 4/20/94. |
| CORP Author |
Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
86940001443 |
| Stock Number |
OTS0558173 |
| Additional Subjects |
Toxicology ;
Health effects ;
Siloxanes/Silicones ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 70131-67-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558173 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
20p |
| Abstract |
The purpose of this study was to evaluate the genetic activity of dimethyl siloxane fluid. The fluid, diluted with dimethyl sulfoxide, was evaluated in Salmonella typhimurium and Escherichia coli reverse mutation assays as outlined in O.E.C.D. (CRF 46 (162)). Salmonella typhimurium (TA1535, TA97, TA98, and TA100) and Escherichia coli (WP2) were plated with dimethyl siloxane fluid concentrations of 312.5, 625, 1250, 2500, or 5000 ug/plate, or with positive or negative controls, both with and without microsomal activation by Aroclor-induced rat liver enzymes and were incubated for 72 hours. Dimethyl sulfoxide served as the negative control, while sodium azide, 4-nitroquinoline-n-oxide, daunomycin. n-methyl- n-nitro-n-nitrosoquanidine, 2-anthramine, and 2-aminofluorene served as positive controls. No evidence of mutagenicity was observed for the test material. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803900 |
| Origin |
NTIS |
| Type |
CAT |
