| Main Title |
Drosophila Melanogaster Sex Linked Recessive Lethal Test of Cyclohexanone with Cover Letter dated 101586 (Final Report). |
| CORP Author |
Wisconsin Univ., Madison.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8666139 |
| Stock Number |
OTS0511205 |
| Additional Subjects |
Toxicology ;
Health effects ;
Cyclohexanone ;
Genotoxicity ;
Gene Mutations ;
Insects ;
Inhalation ;
Toxic substances ;
Laboratory animals ;
CAS No 108-94-1
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0511205 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The ability of cyclohexanone to induce sex-linked recessive lethal mutations in the post-meiotic germ cells was evaluated in Drosophila males (wild-type stock, Canton-S). Based on preliminary toxicity determinations, Drosophila (689, 1343, 1008 and 892/treated groups and 559, 1203, 1213, and 892/control groups) were treated with cyclohexanone via inhalation at vapor concentrations of 0 (control group) or 36% for 4 hours. Surviving flies were mated with 3 sets of 3 virgin 'Basc' females for 72 hours each. Percent mortalities during exposure and the following 21 hours averaged 32% in the treated groups versus 0% in the controls. Male sterility was slightly increased in treated flies. There was no indication of any mutagenic effect in any germ cell stage in treated male Drosophila (percent lethals for treated and control groups were 0.071% and 0.070%, respectively). |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801640 |
| Origin |
NTIS |
| Type |
CAT |
