| Main Title |
Cho/hgprt Test on Cumene with Cover Letter. |
| CORP Author |
Gulf Oil Exploration and Production Co., Oklahoma City, OK.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1985 |
| Report Number |
878216011 |
| Stock Number |
OTS0206775 |
| Additional Subjects |
Toxicology ;
Health effects ;
Cumene (98-82-8) ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Hamsters ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 98-82-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0206775 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
29p |
| Abstract |
The ability of cumene to induce mutations at the gene locus coding for hypoxanthine-guanine phosphoribosyl transferase in Chinese hamster ovary cells (CHO/HGPRT Assay) was evaluated in the presence and absence of metabolic activation from Aroclor-induced rat liver S9 fraction. Based on preliminary cytotoxicity tests, nonactivated cultures were treated with cumene at concentrations of 8, 16, 32, 64, and 128 mcg/ml producing cell survivals relative to the vehicle control (Pluronic F127) of 122.9, 92.8, 104.7, 124.6, and 89.2% respectively. Activated cultures treated with cumene concentrations of 64, 128, 150, and 175 mcg/ml produced relative cell survivals ranging from 91.0 - 7.6%. A significant mutagenic response was not observed in either activated or nonactivated trials. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1985 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801060 |
| Origin |
NTIS |
| Type |
CAT |
