| Main Title |
Cho/hgprt Mammalian Cell Foward Gene Mutation Assay with Acetone Cyanohydrin with Cover Letter dated 04/25/1986. |
| CORP Author |
Pharmakon Research International, Inc., Waverly, PA.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216402 |
| Stock Number |
OTS0510330 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acetone Cyanohydrin (75-86-5) ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Hamsters ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 75-86-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510330 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
123p |
| Abstract |
The ability of acetone cyanohydrin to induce mutations at the HGPRT gene locus in Chinese Hamster Ovary (CHO) cells in vitro was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity determinations, acetone cyanohydrin was tested for mutagenicity at 5 concentrations over the range of 100-950 ug/ml, with cell survival ranging from 101-37% without activation and 102-49% with activation. There were no significant differences between treated and control (untreated) cultures with respect to mutation frequencies at any of the concentrations tested, either with or withoutactivation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Monsanto Chemical Co., Dayton, OH. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A07/MF A07 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801480 |
| Origin |
NTIS |
| Type |
CAT |
