| Main Title |
Salmonella Typhimurium/mammalian Microsome Plate Incorporation Assay with Acetone Cyanohydrin with Cover Letter dated 04/25/1986. |
| CORP Author |
Hazleton Labs. America, Inc., Madison, WI.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216403 |
| Stock Number |
OTS0510331 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acetone Cyanohydrin (75-86-5) ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 75-86-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510331 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
35p |
| Abstract |
The mutagenicity of acetone cyanohydrin was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537, and TA1538, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity determinations, acetone cyanohydrin, diluted with DMSO, was tested for mutagenicity at concentrations of 0, 6.1, 18.3, 55.0, 165, and 495 ug/plate using the plate incorporation method. Acetone cyanohydrin was toxic to all the Salmonella strains at concentrations of 165 and 495 ug/ml without activation and at a concentration of 495 ug/ml with activation. Acetone cyanohydrin did not cause a reproducible positive response in any of the bacterial tester strains, either with or without metabolic activation. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Monsanto Chemical Co., Dayton, OH. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1986 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A04/MF A04 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801490 |
| Origin |
NTIS |
| Type |
CAT |
