| Main Title |
Report to Dow Corning Corporation Mutagenic Study with Tx-740 in Albino Mice with Cover Letter dated 04/20/94. |
| CORP Author |
Industrial Bio-Test Labs., Inc., Northbrook, IL.; Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1994 |
| Report Number |
8EHQ-86940001188 |
| Stock Number |
OTS0572198 |
| Additional Subjects |
Toxicology ;
Health effects ;
TX-740 ;
Toxicity ;
Genotoxicity ;
Gene mutations ;
Mammals ;
Mice ;
Parenteral ;
Intraperitoneal ;
CAS No 63148-62-9 ;
Tx-740 (CAS No 63148-62-9) ;
Toxic substances ;
Laboratory animals
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0572198 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
Dimethylsiloxanes and silicones (CAS No. 63148-62-9) was evaluated in a mutagenic potential study in albino mice. Groups of 12 Charles River male mice were treated with 5 and 10 g/kg of test fluid, 50 mg/kg methyL methanesulfate, or corn oil by intraperitoneal administration and mated with untreated female mice each week for 6 weeks (18 female mice per each male mouse during the 6 weeks of mating). Females were sacrificed approximately 1 week after mating and pre- implantation losses and early resorptions recorded. The number of pre- implantation losses and early resorptions were similar for the treated and control animals. Therefore, the test fluid was considered not mutagenic. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Dow Corning Corp., Midland, MI. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1994 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028804030 |
| Origin |
NTIS |
| Type |
CAT |
