| Main Title |
Oleylamine: L5178y Tk+/- Mouse Lymphoma Mutagenesis Assay with Confirmation (Final Report) with Attachments and Cover Letter Dated 09/29/1989. |
| CORP Author |
Microbiological Associates, Bethesda, MD.; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8984189 |
| Stock Number |
OTS0525406 |
| Additional Subjects |
Toxicology ;
Health effects ;
Oleylamine ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Mice ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 112-90-3
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0525406 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
68p |
| Abstract |
Oleylamine was tested for mutagenicity in vitro in L5178Y TK+/- mouse lymphoma cells, both in the presence and absence of Aroclor-induced rat liver S-9 metabolic activation. Based on preliminary determinations of cytotoxicity, the compound was tested in 3 trials without activation at concentrations ranging from 0.13-0.32, 0.13-1.8, and 0.2-1.0 nl/ml culture medium, and in 3 trials with activation, at 1.3- 10.0, 1.3-13, and 1.5-11 nl/ml. Cell survival without activation ranged from 75-99, 3-110, and 6-109%, for the first, second, and third trials, respectively. Cell survival with activation ranged from 6-106, 13-107,and 2-115%,for the first, second, and third trials, respectively. The treatment did not increase the frequency of forward mutations at the thymidine kinase locus, indicating that the test compound was not mutagenic in mouse lymphoma cells under the conditions of this assay. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Chemical Manufacturers Association, Washington, DC. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802630 |
| Origin |
NTIS |
| Type |
CAT |
