| Main Title |
Mutagenic Activity in the Salmonella/microsome Assay with Attachments, Cover Sheets and Letter Dated 09/24/1984 (Sanitized). |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
86-890000815S |
| Stock Number |
OTS0520932 |
| Additional Subjects |
Toxicology ;
Health effects ;
Methyl Methacrylate (80-62-6) ;
Genotoxicity ;
Gene Mutations ;
Bacteria ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 80-62-6
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0520932 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
The mutagenicity of methacrylic acid, methyl ester was evaluated in Salmonella tester strains TA98, TA100, TA1535, and TA1537 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at doses of 0, 1000, 2500, 5000, 7500, and 10000 ug/plate using the direct plate incorporation method; mutagenicity was additionally tested for in strain TA100 at concentrations of 0, 10, 25, and 50 mM using the suspension assay. The material was found to be mutagenic in strain TA100, in the presence of activation, in the suspension assay. Methacrylic acid, methyl ester did not cause a reproducible positive response in tester strains TA98, TA100, TA1535, or TA1537, either in the presence or absence of added metabolic activation, in the direct plate incorporation assay. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802290 |
| Origin |
NTIS |
| Type |
CAT |
