| Main Title |
Letter from American Petroleum Institute to US EPA regarding Submission of 8(e) Information on Three Commercial Solvents with Attachments. |
| CORP Author |
American Petroleum Inst., Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1977 |
| Report Number |
8EHQ-1077-0010 |
| Stock Number |
OTS0200393 |
| Additional Subjects |
Toxicology ;
Health effects ;
Petroleum hydrocarbons ;
Genotoxicity ;
Chromosomal effects ;
Mammals ;
Rats ;
Parenteral ;
Mice ;
Subcutaneous ;
Gene mutations ;
Bacteria ;
CAS No 1130-20-7 ;
CAS No 8052-41-3 ;
CAS No 64741-46-4 ;
CAS No 64741-66-8 ;
CAS No 64741-84-0 ;
CAS No 64741-98-6 ;
CAS No 64741-99-7 ;
CAS No 64742-81-0 ;
CAS No 64742-88-7 ;
CAS No 64742-89-8 ;
CAS No 64742-94-5 ;
CAS No 64742-95-6 ;
CAS No 64742-96-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0200393 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
880p |
| Abstract |
Mutagenicity studies were conducted on 3 petroleum fractions: rubber solvent, (identified as either a single chemical or a mixture of CAS 64742-89-8 and 64741-84-0); 60 solvent,(a blend of any or all of the following: CAS 64741-46-4, 64741-66-8, 64741-99-7, 64741-84-0, 64742-88-7, 64742-95-6), and high aromatic solvent, (either a single chemical or mixture of CAS 64742-95-6, 64742-94-5, 64741-99-7, 64741-98-6). Cytogenetic assays were conducted with male Long-Evans rats (30/group) administered 1.5 ml/kg of a negative control of 1.5 ml/kg water, or 20 mg/kg of the positive control, 7,12- dimethylbenz(a)anthracene by intraperitonal injection. Increased Type I and Type II chromosomal aberrations were observed in both and within 1 day, and showed increased Type I aberrations within 7 days post-treatment. Three-tier testing of (I) and (II) showed the following: no evidence of mutagenicity in microsome plate assays with 5 tester strains of Salmonella typhimurium and Saccharomyces cerevisiae strain D4, with and without S9; no evidence of forward mutations in the L5178Y mouse lymphoma assay; no evidence of chromosomal aberrations in the cytogenetic analysis of bone marrow cells from exposed male Sprague-Dawley rats; and no evidence of compound-induced lethality in the dominant lethal assay with rats. Ten additional petroleum fractions tested for dominant lethality to mice showed no evidence of mutagenic potential. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
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| PUB Date Free Form |
Oct 1977 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A99/MF A99 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500450 |
| Origin |
NTIS |
| Type |
CAT |
