| Main Title |
Initial Submission: Letter from Nicca U.S.A. Inc. to USEPA regarding Genotoxicity Testing of Phenol, 2-((4-Hydroxyphenyl)-Sulfonyl) with Attachments and dated 03/05/1996. |
| CORP Author |
Inveresk Research International Ltd., Musselburgh (Scotland).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1996 |
| Report Number |
8EHQ-0396-13605 |
| Stock Number |
OTS0558479 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Phenol 2-((4-Hydroxyphenyl)Sulfonyl) ;
Genotoxicity ;
Chromosomal effects ;
Mammals ;
Hamsters ;
In vitro ;
Gene mutations ;
Bacteria ;
CAS No 5397-34-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558479 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
83p |
| Abstract |
BPS-24 was submitted for testing and evaluation of clastogenic potential. Chromosomal aberrations assays were performed with duplicate, Chinese hamster ovary (CHO) cell cultures. This study was conducted incorporating 2 independent tests. Dimethylsulphoxide (DMSO) was the vehicle and cyclophosphamide and methyl methanesulphonate were the positive controls used in both experiments. Both tests were conducted in both the presence and absence of a post-mitochondrial supernatant fraction obtained from the livers of adult, male rats treated with Aroclor 1254 (S9) and an NADPH-generating system. Cultures, established approximately 20 hours before testing, were treated for 6 h in the presence or 22 hours in the absence of 59 mix. Cultures were harvested at 24 h (Test 1 and 2) or 48 h (Test 2) post treatment. BPS-24 was toxic to Chinese hamster ovary cells in vitro when tested to the maximum permitted concentration of 5000 micro g. ml(sup -1) in Test 1. Toxicity was noted in cultures treated with 313-5000 micro g.ml(sup -1) in the presence and 625-5000 micro g.ml(sup -1) in the absence of S9 mix. In Test 2, cultures were tested with 78-625 micro g. ml(sup -1) in both the presence and absence of S9 mix. Toxicity was noted in cultures treated with 313-625 micr g.ml(sup -1) in the presence and 234-625 micro g.ml(sup -1) in the absence of S9 mix. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
12 Mar 1996 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A06/MF A06 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500160 |
| Origin |
NTIS |
| Type |
CAT |
