| Main Title |
In Vitro Microbial Mutagenicity Studies of Isocyanic Acid, Methylene Di-para-phenylene Ester with Cover Letter dated 04/30/1984. |
| CORP Author |
Du Pont de Nemours (E.I.) and Co., Wilmington, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1984 |
| Report Number |
FYI-AX-0584-0303 |
| Stock Number |
OTS0000303-0 |
| Additional Subjects |
Toxicity ;
Health effects ;
Genotoxicity ;
Gene mutations ;
Bacteria ;
In vitro ;
CAS No 101-68-8
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0000303-0 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
63p |
| Abstract |
Methylenedi-para-phenylene ester of isocyanic acid was examined in Salmonella typhimurium tester strains TA1535, TA1537, TA1538, TA98 and TA100 with and without rat liver homogenate S9 fraction to provide metabolic activation. Using the plate incorporation technique at doses of 0.5, 1.0, 1.5, 2.0 and 2.5 mg/plate, the test article was found to be mutagenic to strains TA98 and TA100 in the presence of activation; the greatest effect (0.27 revertants/uMol) was observed in TA100. In the absence of activation, a mutagenic effect was not observed in any strains. The investigators reported that preliminary cytotoxicity screening had been performed. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
Apr 1984 |
| Category Codes |
57Y; 57U; 68G; 99; 48G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
010500410 |
| Origin |
NTIS |
| Type |
CAT |
