| Main Title |
Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells. |
| Author |
Dearfield, K. L. ;
Millis, C. S. ;
Harrington-Brock, K. ;
Doerr, C. L. ;
Moore, M. M. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Durham, NC. |
| Publisher |
c1989 |
| Year Published |
1989 |
| Report Number |
EPA/600/J-89/227; |
| Stock Number |
PB90-146036 |
| Additional Subjects |
Toxicity ;
Lymphomas ;
Acrylates ;
Methacrylates ;
Tables(Data) ;
Graph(Charts) ;
Mice ;
Mutations ;
Cell nucleus ;
Esters ;
Reprints ;
Mutagenicity tests ;
Dose-response relationships ;
Risk assessment ;
Cultured cells
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-146036 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
15p |
| Abstract |
Nine acrylate/methacrylate esters were tested for the induction of mutations, aberrations, and micronuclei in cultured L5178Y mouse lymphoma cells without exogenous activation. With the exception of 2-ethylhexyl acrylate, and dicyclopentenyloxyethyl methacrylate which produced equivocal responses, the other seven compounds (2-hydroxyethyl acrylate, dicyclopentenyloxyethyl acrylate, tetraethylene glycol diacrylate, tetraethylene glycol dimethacrylate, trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, and pentaerythritol triacrylate) produced positive genotoxic responses with different potencies. Primarily small-colony, TFT-resistant mutants were induced, suggesting a clastogenic mechanism that was supported by increased aberration and micronucleus frequencies. Generally, it was found that multifunctional compounds (esters with more than 1 functional vinyl group) required lower concentrations than monofunctional compounds to induce maximal cytotoxic, mutagenic, and clastogenic responses. In addition, acrylates were generally more potent than their corresponding methacrylates. |
| Supplementary Notes |
Pub. in Mutagenesis, v4 n5 p381-393 1989. Prepared in cooperation with Environmental Health Research and Testing, Inc., Durham, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Analysis of the Genotoxicity of Nine Acrylate/Methacrylate Compounds in L5178Y Mouse Lymphoma Cells. |
| Category Codes |
57Y; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
007530399 |
| Origin |
NTIS |
| Type |
CAT |
