| Main Title |
Increased Pulmonary Disease Mediated through Altered Bacterial Defenses. |
| Author |
Gardner, Donald E. ;
Graham., Judith A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div. |
| Year Published |
1977 |
| Report Number |
EPA/600/J-77/094; |
| Stock Number |
PB-278 586 |
| Additional Subjects |
Respiratory diseases ;
Immunology ;
Lung ;
Immunity ;
Phagocytes ;
Bacteria ;
Air pollution ;
Ozone ;
Nitrogen ;
Trace elements ;
Toxicology ;
Laboratory animals ;
Experimental data ;
Reprints ;
Immunosuppression ;
Muramidase ;
Macrophages ;
Pulmonary surfactants ;
Air pollution effects(Humans)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-278 586 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
25p |
| Abstract |
The process of infection has been defined as an interaction of a host, a microbe, and the environment. In the natural environment, healthy individuals exist in equilibrium with potentially pathogenic microorganisms. Using this concept, an animal-model system was developed to study the effects of pollutants that can affect this equilibrium and result in acute pulmonary disease. Increase of mortality from exposure to several pathogenic organisms has been reported for a variety of animal species after exposure to ozone, nitrogen dioxide, and a variety of trace metals. There are a number of possible mechanisms by which the lung can become more vulnerable to microorganisms. These include (1) reduction in deposition or retention of bacteria, (2) slowing of physical removal of bacterial cells by the mucociliary mechanisms, (3) dysfunction of the alveolar macrophages, (4) alteration of the acellular lining material (surfactant) of the deep lung, (5) the presence of edema fluid or inflammatory exudate in the airway, and (6) pulmonary immunosuppression. The influence of environmental pollutants on each of these factors is discussed. |
| Supplementary Notes |
Pub. in Pulmonary Macrophage and Epithelial Cells, ERDA Symposium Ser-43, pl-20. Proceedings of the Annual Hanford Biology Symposium (16th), Richland, Wash. 27-29 Sep 76, 1977. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Increased Pulmonary Disease Mediated through Altered Bacterial Defenses. |
| PUB Date Free Form |
1977 |
| Category Codes |
6E; 6T; 68G; 68A; 57E; 57J; 57Y |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
323736908 |
| Origin |
NTIS |
| Type |
CAT |
