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Main Title Inhalation Studies of Mt. St. Helens Volcanic Ash in Animals. 2. Lung Function, Biochemistry, and Histology.
Author Raub, J. A. ; Hatch, G. E. ; Mercer, R. R. ; Grady, M. ; Hu, P. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/129;
Stock Number PB86-100211
Additional Subjects Toxicology ; Volcanic ejecta ; Respiration ; Lung ; Sulfur dioxide ; Rats ; Laboratory animals ; Reprints ; Mount St Helen ; Air pollution effects(Animals) ; Inhalation provocation tests
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NTIS  PB86-100211 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract Rats were exposed by inhalation to 9.4 mg/m3 size-fractionated volcanic ash for 5 days (2hr/day) and examined for changes in pulmonary function and histology for periods of up to 1 year. Fine-mode volcanic ash, SO2, and a combination of ash and SO2 produced no observable effects in normal rats and rats with elastase-induced emphysema. However, there was a mild irritant response to SO2 which was not influenced by the volcanic ash. Rats injected intratracheally with fine-mode volcanic ash or saline showed no evidence of pulmonary alterations after 6 months. Those injected with coarse-mode volcanic ash showed minor pulmonary functional changes, histologically detectable alveolitis, and small increases in lung weight. In contrast, quartz-injected rats showed large alterations in pulmonary function, lung weight, hydroxyproline levels, and large areas of lung consolidation and fibrosis. (Copyright (c) 1985, Academic Press, Inc.)
Supplementary Notes See also PB85-198851, and PB86-100203. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
Availability Notes Pub. in Environmental Research 37, p72-83 Jun 85.
NTIS Title Notes Journal article.
Title Annotations Reprint: Inhalation Studies of Mt. St. Helens Volcanic Ash in Animals. 2. Lung Function, Biochemistry, and Histology.
PUB Date Free Form c1985
Category Codes 6T; 8G; 6F; 57Y; 57H; 48F
NTIS Prices Not available NTIS
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 533917084
Origin NTIS
Type CAT