Main Title |
Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis. |
Author |
Busch, R. H. ;
Lauhala, K. E. ;
Loscutoff, S. M. ;
McDonald, K. E. ;
|
CORP Author |
Battelle Pacific Northwest Labs., Richland, WA.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/067; |
Stock Number |
PB84-232685 |
Additional Subjects |
Respiratory diseases ;
Emphysema ;
Pulmonary emphysema ;
Rats ;
Laboratory animals ;
Dosage ;
Toxicity ;
Reprints ;
Elastase ;
Morphogenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-232685 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
19p |
Abstract |
Emphysema was produced experimentally in rats by administration of porcine pancreatic elastase at dose levels of 75, 100, 125, and 150 units elastase activity/100 g body wt. All doses studied were equally effective in producing emphysema. Dose levels of over 75 units activity/100 g offered no advantage in terms of degree or severity of emphysema produced; however, such doses exacerbated hemorrhage and edema, resulting in relatively high post-instillation mortality. Lesion morphogenesis at all doses tested paralleled those described in this and in other species by other investigators. The 75-unit activity produced a quantifiable degree of emphysema which was relatively constant among animals. Results suggest that because of group differences in susceptibility to elastase (or variations in batches of elastase), dose-range studies should be performed on each new group of animals. |
Availability Notes |
Pub. in Environmental Research 33, p497-513 1984. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Experimental Pulmonary Emphysema Induced in the Rat by Intratracheally Administered Elastase: Morphogenesis. |
PUB Date Free Form |
c1984 |
Category Codes |
6O; 6T; 57Q; 57Y |
NTIS Prices |
Not available NTIS |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
432820566 |
Origin |
NTIS |
Type |
CAT |