| Main Title |
Interaction between Water Pollutants: Quantitative Electron Microscopy of Hepatic Morphological Changes Induced by 1,2-Dichloroethane (DCE) and 1,1-Dichloroethylene (VDC). |
| Author |
Gray, R. H. ;
|
| CORP Author |
Michigan Univ., Ann Arbor. Dept. of Environmental and Industrial Health.;Health Effects Research Lab., Cincinnati, OH. |
| Publisher |
Jul 89 |
| Year Published |
1989 |
| Report Number |
EPA-R-812556; EPA/600/1-89/005; |
| Stock Number |
PB89-214126 |
| Additional Subjects |
Water supply ;
Ground water ;
Drinking water ;
Public health ;
Toxicity ;
Laboratory animals ;
Dosage ;
Electron microscopy ;
Exposure ;
Experimental design ;
Molecular structure ;
Cells(Biology) ;
Water pollution effects(Humans) ;
Ethane/dichloro ;
Ethylene/dichloro
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-214126 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
136p |
| Abstract |
Numerous chemicals are found as contaminants in public water supplies which constitute potential public health hazards. The studies were designed to determine the early histopathological effects of two known water contaminants, 1,2-dichloroethane (DCE) and 1,1-dichloroethylene (VDC), administered alone or in mixtures to laboratory rats. Both agents have been shown to cause cytotoxic responses in kidney and liver. Hepatic tissues were removed and prepared for quantitative electron microscopic studies. Significant changes were seen in cell, cytoplasmic and nuclear volumes, except in the high dose DCE group (600 mg/kg). Comparison of measured parameters of the single dosed animals with the mixed dosed exhibited the most significant differences in the lipid droplet compartment. |
| Supplementary Notes |
Sponsored by Health Effects Research Lab., Cincinnati, OH. |
| NTIS Title Notes |
Summary rept. |
| Category Codes |
57Y; 57U; 68D; 68G |
| NTIS Prices |
PC A07/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
925826787 |
| Origin |
NTIS |
| Type |
CAT |
