| Main Title |
Health assessment document for vinylidene chloride. |
| Author |
Basu, D. K. ;
Becker, J. ;
Colman, J. T. ;
Neal, M. W. ;
Santodonato, J.
|
| CORP Author |
Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. ;Syracuse Research Corp., NY. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, |
| Year Published |
1985 |
| Report Number |
EPA-600/8-83-031 F |
| Stock Number |
PB86-100641 |
| OCLC Number |
12691673 |
| Subjects |
Dichloroethylene--Toxicology
|
| Additional Subjects |
Dichloroethylene--Toxicology ;
Environmental surveys ;
Vinylidene chloride resins ;
Toxicology ;
Hazardous materials ;
Air pollution ;
Ecology ;
Assessments ;
Exposure ;
Molecular structure ;
Urban areas ;
Public health ;
Soils ;
Mutagens ;
Carcinogens ;
Transport properties ;
Water pollution ;
Risk ;
Sources ;
Physical properties ;
Solid waste disposal ;
Air pollution ;
Environmental health ;
Toxic substances ;
Air pollution effects(Animals) ;
Air pollution effects(Humans) ;
Health risks ;
Air pollution effects(Plants) ;
Point sources ;
Land pollution ;
Monomers ;
Pharmacokinetics
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
RA1242.D453H43 1985 |
|
Region 1 Library/Boston,MA |
04/29/2016 |
| EJED |
EPA 600/8-83-031F |
|
OCSPP Chemical Library/Washington,DC |
01/01/1988 |
| EKBD |
EPA-600/8-83-031F |
|
Research Triangle Park Library/RTP, NC |
03/19/2004 |
| ELBD ARCHIVE |
EPA 600-8-83-031F |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD |
EPA 600-8-83-031F |
|
AWBERC Library/Cincinnati,OH |
01/28/1989 |
| ERAD |
EPA 600/8-83-031 F |
|
Region 9 Library/San Francisco,CA |
02/19/2013 |
| ESAD |
EPA 600-8-83-031F |
|
Region 10 Library/Seattle,WA |
03/23/2010 |
| NTIS |
PB86-100641 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) : illustrations ; 28 cm |
| Abstract |
Vinylidene chloride is a highly reactive, flammable, clear colorless liquid. In the absence of chemical inhibitors, it can produce violently explosive, complex peroxides. The estimated, ambient air level of vinylidene chloride in urban-suburban areas of the United States is 20 micrograms/cu m. The median concentration (14 micrograms/cu m) for ambient air at point sources of emission is substantially higher. Following oral or inhalation exposure, mammals readily absorb vinylidene chloride. Metabolites of vinylidene chloride, formed in the liver, produce toxic lesions in the liver and kidneys (the target organs), with inhibitors of metabolism providing protection from vinylidene chloride toxicity. The acute hepatotoxicity of vinylidene chloride is greater than that of any other chloroethylene. Based on the overall evidence, VDC would be a Group 3 chemical according to the IARC (International Agency for Research in Cancer's) approach, and by definition, a Group 3 chemical cannot be classified according to its carcinogenicity to humans. However, the mutagenic activity of VDC, its chemical structure, its activity as a tumor initiator in mouse skin, and the ability of its metabolites to react with DNA raise concern that the total body of evidence should not be lightly dismissed. |
| Notes |
"August 1985." Cover: "Final Report." "EPA-600/8-83-031F." Includes bibliographical references. |
| Place Published |
Research Triangle Park, N.C. |
| Supplementary Notes |
See also PB84-126762. Prepared in cooperation with Syracuse Research Corp., NY. |
| PUB Date Free Form |
1985 |
| NTIS Prices |
PC A14/MF A01 |
| BIB Level |
m |
| Document Type |
BC |
| Medium |
unmediated |
| Content |
text |
| Carrier |
volume |
| Cataloging Source |
OCLC/T |
| OCLC Time Stamp |
20160419144058 |
| Language |
eng |
| Origin |
OCLC |
| Type |
MERGE |
| OCLC Rec Leader |
01123cam 2200289Ia 45020 |
