| Main Title |
Reanalysis and Clarification of the Structures of alpha-Naphthoflavone Dihydrodiols Formed by Uninduced and Induced Rat Liver Microsomes from Charles River CD and Sprague-Dawley Rats. |
| Author |
Nesnow, S. ;
Bryant, B. J. ;
Rudo, K. ;
Easterling, R. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-600/J-83-218; |
| Stock Number |
PB84-206127 |
| Additional Subjects |
Toxicology ;
Liver neoplasms ;
Metabolism ;
Environmental surveys ;
Molecular structure ;
Laboratory animals ;
Rats ;
Ribosomes ;
Comparison ;
Water pollution ;
Reprints ;
Naphthopyranone/phenyl ;
Benzoflavone ;
Water pollution effects(Animals) ;
Cancer ;
Naphthopyranone dihydrodiol/phenyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-206127 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The structures of alpha-naphthoflavone (ANF) dihydrodiols formed by uninduced and induced rat liver microsomes are identified by conversion of the metabolically formed ANF-dihydrodiols to the corresponding phenols. Comparison of these phenols with synthetic standards provides an unambiguous method for structural identification. The results of these studies are that hepatic microsomes from uninduced or phenobarbital, Aroclor-1254, 3-methylcholanthrene, or 5,6-benzoflavone induced Sprague-Dawley or Charles River CD rats each produce a major and a minor ANF-dihydrodiol identified as ANF-7,8-dihydrodiol and ANF-5,6-dihydrodiol, respectively. |
| Availability Notes |
Pub. in Carcinogenesis, v4 n4 p425-430 1983. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Reanalysis and Clarification of the Structures of alpha-Naphthoflavone Dihydrodiols Formed by Uninduced and Induced Rat Liver Microsomes from Charles River CD and Sprague-Dawley Rats. |
| PUB Date Free Form |
c1983 |
| Category Codes |
6A; 6T; 7D; 68D; 57B; 57Y; 68G; 99F |
| NTIS Prices |
Not available NTIS |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
424418669 |
| Origin |
NTIS |
| Type |
CAT |
