| Main Title |
Assessment of the Propensity for Covalent Binding of Electrophiles to Biological Substrates. |
| Author |
Carlson, R. M. ;
|
| CORP Author |
Minnesota Univ.-Duluth.;Environmental Research Lab.-Duluth, MN. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA-R813144-02 ;EPA-R813943; EPA/600/J-90/251; |
| Stock Number |
PB91-144949 |
| Additional Subjects |
Deoxyribonucleic acids ;
Electrophilic reactions ;
Chemical bonds ;
Carbonium ions ;
Molecular structure ;
Molecular biology ;
Reprints ;
Hard and soft acids
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-144949 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Electrophilic character is associated with the ability of external agents to interact with centers of electron density in biological macromolecules and to cause the interruption or alternation of normal activity. With the observation of site specificity in mutagenic events, Pearson's hard/soft acid-based (HSAB) theory is presented as a useful concept in correlating chemical observations in the absence of detailed direct knowledge of the process. Methods for the evaluation of carbon electrophiles (e.g., carbocation character) as reactants are reviewed as potential physical parameters that could be applied in developing quantitative structure-activity relationships. |
| Supplementary Notes |
Pub. in Environmental Health Perspectives, v87 p227-232 1990. Sponsored by Environmental Research Lab.-Duluth, MN. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Assessment of the Propensity for Covalent Binding of Electrophiles to Biological Substrates. |
| Category Codes |
99F; 57F |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
109129933 |
| Origin |
NTIS |
| Type |
CAT |
