| Main Title |
Predicting Modes of Toxic Action from Chemical Structure: An Overview. |
| Author |
Bradbury, S. P. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. |
| Publisher |
1994 |
| Year Published |
1994 |
| Report Number |
EPA/600/J-94/258; |
| Stock Number |
PB94-176195 |
| Additional Subjects |
Toxicity ;
Fishes ;
Water pollution effects(Animals) ;
Aquatic animals ;
Dose-response relationships ;
Marine biology ;
Hazardous materials ;
Exposure ;
Chemical properties ;
Biological effects ;
Predictions ;
Molecular structure ;
Mutagens ;
Carcinogens ;
Reprints ;
QSAR(Quantitative structure activity relationships)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB94-176195 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
18p |
| Abstract |
In the field of environmental toxicology, and especially aquatic toxicology, quantitative structure activity relationships (QSARs) have developed as scientifically-credible tools for predicting the toxicity of chemicals when little or not empirical data are available. A basic and fundamental understanding of toxicological principles has been considered crucial to the continued acceptance and application of these techniques as biologically relevant. As a consequence, there has been an evolution of QSAR development and application from that of a chemical-class perspective to one that is more consistent with assumptions regarding modes of toxic action. The assessment of a compound's likely mode of toxic action is critical for a correct QSAR selection; incorrect mode of action-based QSAR selections can result in 10- to 1000-fold errors in toxicity/predictions. (Copyright (c) 1994 Gordon and Breach Science Publishers S.A.) |
| Supplementary Notes |
Pub. in SAR and QSAR in Environmental Research, v2 p89-104 1994. Presented at the International Workshop on QSAR in Environmental Toxicology, Duluth, MN., July 19-23, 1992. See also PB93-192631. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Predicting Modes of Toxic Action from Chemical Structure: An Overview. |
| Category Codes |
68D; 57Y; 47D |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
420325071 |
| Origin |
NTIS |
| Type |
CAT |
