Main Title |
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets / |
Author |
Boelsterli, Urs A.,
|
Publisher |
CRC Press, |
Year Published |
2007 |
OCLC Number |
74459862 |
ISBN |
9780849372728; 0849372720 |
Subjects |
Molecular toxicology ;
Toxicology--methods ;
Molecular Biology--methods ;
Signal Transduction ;
Xenobiotics--pharmacokinetics ;
Xenobiotics--toxicity ;
Toxicologia ;
Transduðcäao de sinal celular ;
Biologia molecular
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
RA1220.3.B64 2007 |
|
Research Triangle Park Library/RTP, NC |
08/08/2011 |
ELBM |
RA1220.3.B64 2007 |
|
AWBERC Library/Cincinnati,OH |
08/29/2008 |
ELDM |
RA1220.3.B64 2007 |
|
CCTE/GLTED Library/Duluth,MN |
12/06/2010 |
|
Edition |
2nd ed. |
Collation |
399 p. : ill. ; 25 cm. |
Notes |
Includes bibliographical references and index. |
Contents Notes |
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology. |
Place Published |
Boca Raton |
PUB Date Free Form |
c2007 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
LCCN |
2006035219 |
OCLC Time Stamp |
20110805084639 |
Language |
eng |
Origin |
OCLC |
Type |
CAT |
OCLC Rec Leader |
02887cam 2200565Ka 45020 |