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OLS Field Name OLS Field Data
Main Title Spermatid Micronucleus Analyses of Trichloroethylene and Chloral Hydrate Effects in Mice.
Author Allen, J. W. ; Collins, B. W. ; Evansky, P. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher cFeb 94
Year Published 1994
Report Number EPA/600/J-94/316;
Stock Number PB94-197209
Additional Subjects Toxicology ; Micronucleus tests ; Spermatids ; Chloral hydrate ; Trichloroethylene ; Chromosome deletion ; Mice ; Antibodies ; Dose-response relationships ; Meiosis ; Reprints ;
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NTIS  PB94-197209 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/11/1994
Collation 13p
Abstract Mice were exposed by inhalation to trichloroethylene (TCE) or by i.p. injection to the TCE metabolite, chloral hydrate (CH). Early spermatids were analyzed for micronucleus (MN) frequency and the presence or absence of kinetochore(s) using fluorochrome-labeled anti-kinetochore antibodies. It was determined that 5 consecutive days of exposure to 5, 50 or 500 ppm TCE during preleptotene through early pachytene stages of meiotic cell development do not result in increased frequencies of spermatid MN. CH at 41, 83 or 165 mg/kg was positive for spermatid MN induction when treatments corresponded to spermatogonial stem cell or preleptotene spermatocyte stages of development; negative results were obtained after treatments of leptotene-zygotene or diakinesis-metaphase stages. The significantly increased levels of MN observed were invariably of the kinetochore-negative type. (Copyright (c) 1994 Elsevier Science B.V.)
Supplementary Notes Pub. in Mutation Research Letters 323, n2 p81-88 Feb 94. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Spermatid Micronucleus Analyses of Trichloroethylene and Chloral Hydrate Effects in Mice.
Category Codes 57Y; 57F
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 425927296
Origin NTIS
Type CAT