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RECORD NUMBER: 98 OF 1249

Main Title Carcinogenicity of Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Dichloroacetic Acid, in Mouse Liver.
Author Herren-Freund, S. L. ; Pereira, M. A. ; Khoury, M. D. ; Olson, G. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Pathology Associates, Inc., Cincinnati, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-68-03-3215; EPA/600/J-87/275;
Stock Number PB88-185541
Additional Subjects Acetic acid ; Liver neoplasms ; Mice ; Adenoma ; Carcinogens ; Phenobarbital ; Drugs ; Toxicity ; Toxicology ; Potable water ; Contaminants ; Water pollution ; Reprints ; Trichloroacetic acid ; Trichloroethylene ; Dichloroacetate ; Drug synergism ; Ethylnitrosourea
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NTIS  PB88-185541 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Abstract Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when given by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic acid (DCA) as a minor metabolite. These chlorinated acetic acids have not been shown to be genotoxic; although, they have been shown to induce peroxisome proliferation. Therefore, the authors determined the ability of TCE, TCA, or DCA to act as tumor promoters in mouse liver. Therefore our results demonstrate that DCA and TCA are hepatocarcinogens in B6C3F1 mice although there has been no previous evidence of their geonotoxicity. (Copyright (c) 1987 by Academic Press, Inc.)
Supplementary Notes Pub. in Toxicology and Applied Pharmacology, v90 n2 p183-189 Sep 87. Prepared in cooperation with Pathology Associates, Inc., Cincinnati, OH. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Carcinogenicity of Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Dichloroacetic Acid, in Mouse Liver.
PUB Date Free Form c1987
Category Codes 57B; 57E; 57Q; 57Y; 99A
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 816223037
Origin NTIS
Type CAT