| Main Title |
Carcinogenic Activity of Acrylamide in the Skin and Lung of Swiss-ICR Mice. |
| Author |
Bull, R. J. ;
Robinson, M. ;
Stober, J. A. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1984 |
| Report Number |
EPA/600/J-84/165; |
| Stock Number |
PB85-146173 |
| Additional Subjects |
Toxicology ;
Skin(Anatomy) ;
Mice ;
Laboratory animals ;
Dosage ;
Reprints ;
Carcinogenesis ;
Acrylamide
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB85-146173 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
Doses of acrylamide ranging from 12.5 to 50 mg/kg were administered orally to female ICR-Swiss mice over a M, W & F for two weeks (total doses of 75, 150 and 300 mg/kg). Two weeks later some of the animals were begun on a promotion schedule involving the application of 2.5 micrograms TPA/mouse three times weekly. Development of tumors was observed weekly in the skin and in the lungs at one year. Acrylamide was found to initiate squamous cell adenoma and carcinomas in the skin and increased the yield of adenomas and carcinomas in the lung. Skin tumor development was dependent upon TPA promotion whereas lung tumor induction was not. These data extend previous observations of carcinogenic activity of acrylamide in the skin Sencar mice and lungs of strain A/J mice to a third strain of mouse the ICR-Swiss. |
| Supplementary Notes |
Pub. in Cancer Letters 24, p209-212 1984. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Carcinogenic Activity of Acrylamide in the Skin and Lung of Swiss-ICR Mice. |
| PUB Date Free Form |
1984 |
| Category Codes |
6T; 6O; 57Y; 57O |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
507415520 |
| Origin |
NTIS |
| Type |
CAT |
