| Main Title |
Prechronic Test Phase Review. |
| CORP Author |
; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
2000 |
| Report Number |
40-8275009 |
| Stock Number |
OTS0509932 |
| Additional Subjects |
Toxicology ;
Health effects ;
1 ;
2-butylene Oxide ;
Subchronic Toxicity ;
Mammals ;
Rats ;
Inhalation ;
Mice ;
Toxic substances ;
Laboratory animals ;
CAS No 106-88-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0509932 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
Subchronic inhalation toxicity was evaluated in a range finding study using 1,2 epoxybutane (purity not reported) to determine the exposure concentrations for a chronic study. Groups of 20 Fischer-344 rats (10 male, 10 female) and 20 B6C3F1 mice (10 male, 10 female) were exposed to 0,50,100,200,400 or 800 ppm 1,2 epoxybutane for 13 weeks. The number of hours/day and days/week of exposure were not reported. The investigators observed severe inflammation of the nasal cavity, hemorrhage of the tracheobronchial lymph nodes, and statistically significantly decreased body weight gain in rats exposed at 800 ppm; the incidence and severity of lesions in rats exposed at other levels were not considered to be different from controls. Observations in mice exposed to 800 ppm included inflammation of the nasal cavity, red discoloration of the lungs, paleness of the spleen, distension of the G.I. tract, thymic necrosis, thymic atrophy, splenic atrophy, splenic necrosis, along with renal tubular necrosis and inflammation. At 200 and 400 ppm mice exhibited a reduction in the number of cell layers in the olfactory epithelium and an increase in amount of serous fluid, especially in the recesses of the turbinate area; but no effects on the thymus, spleen or kidneys. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
2000 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028801350 |
| Origin |
NTIS |
| Type |
CAT |
