| Main Title |
Mouse Liver Tumor Data: Assessment of Carcinogenic Activity. |
| Author |
Pereira, M. A. ;
|
| CORP Author |
Health Effects Research Lab., Cincinnati, OH. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/350; |
| Stock Number |
PB86-175452 |
| Additional Subjects |
Toxicology ;
Neoplasms ;
Liver ;
Mice ;
Pathology ;
Reprints ;
Carcinogenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-175452 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
25p |
| Abstract |
A significant number of chemicals have been shown to be carcinogenic in mouse liver while lacking carcinogenic activity in other organs or tissues of mice or rats. The review focus on the reasons for the unique susceptibility of the mouse liver to these carcinogens, and the extent the carcinogenic activity of a chemical in mouse liver can be used to predict carcinogenicity in humans. Many of these mouse liver carcinogens lack genotoxic activity and as such have been proposed to be tumor promoters. The limited amount of evidence for their tumor promoting activity is reviewed. Two mechanisms are reviewed that may explain the action of non-genotoxic carcinogens in mouse liver. These are (1) direct-action on precursor cancer cells, either to accelerate their growth or to prevent their death, and (2) the selective growth advantage, resulting from regenerative hyperplasia of precursor cancer cells in response to the necrosis of normal cells produced by hepatotoxins. |
| Supplementary Notes |
Pub. in Toxicology and Industrial Health, v1 n4 p311-333 Dec 85. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Mouse Liver Tumor Data: Assessment of Carcinogenic Activity. |
| PUB Date Free Form |
1985 |
| Category Codes |
6T; 6E; 57Y; 57O |
| NTIS Prices |
PC A02/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
614222723 |
| Origin |
NTIS |
| Type |
CAT |
