| Main Title |
Mouse ear Swelling Test of Diethylamine. |
| CORP Author |
Bio-Dynamics Research and Development Corp., Eugene, OR.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1987 |
| Report Number |
86-870000814 |
| Stock Number |
OTS0515252 |
| Additional Subjects |
Toxicology ;
Health effects ;
Diethylamine (109-89-7) ;
Primary Dermal Sensitization ;
Mammals ;
Mice ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 109-89-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0515252 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
19p |
| Abstract |
The dermal sensitization potential of diethylamine (CAS No. 109-89-7) was evaluated in 10 CF1(BR) mice inducted with 3 daily 0.1 mL topical applications of a 1.0% (v/v) test solution to clipped abdomens. A group of 10 mice likewise inducted over 3 days with 0.1 mL dermal applications of 0.5% DNCB served as the positive control. Challenge and rechallenge were administered 7 and 14 days later in dermal applications of a 50% solution to both dorsal and ventral surfaces of the left and right ears, respectively, of inducted test mice. Ear thickness measured at 24 and 48-hour evaluations indicated the degree of sensitization. Challenge and rechallenge elicited no response in either test or irritation control groups at 24 or 48-hour evaluations. Conversely, 80% and 100% positive response in the DCNB-inducted and challenged groups at 24-hour and 48-hour evaluations, respectively, confirmed the validity of the test system. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1987 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A03/MF A03 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028802000 |
| Origin |
NTIS |
| Type |
CAT |
